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If you have cholelithiasis (gallbladder stones) that are not causing symptoms, your doctor would probably not suggest any treatment. However, if you are having gallstones along with symptoms such as pain, fever, nausea, etc., contact your doctor. You may need oral dissolution therapy such as Ursodiol that contains bile acids that can break up gallbladder stones. Gallstone medicines work best to break up cholesterol stones. You may need to take the medicines for months to years to break up all stones.