- Breast tenderness
- Weight changes
NOTE :These are a few common side effects of Premarin Cream. If any of these side effects persist or worsen, seek medical attention right away. Tell your physician if you have any serious side effects, such as mental or mood changes (depression or memory loss), breast lumps, unusual vaginal bleeding, vaginal irritation/itching, foul odor/discharge, severe abdominal pain, persistent, dark urine, swelling hands or ankles, or increased thirst or urination.