Vardnenafil is a PDE-5 inhibitor that is used to treat erectile dysfunction. The trade name of Vardnenafil is Levitra, a drug that is prescribed for impotency. But unlike other forms of generic Viagra, Vardnenafil is not limited to only this ailment; it is also effective against the disorder of early release of seminal fluid.  These two are the most common symptoms of men suffering from sexual dysfunction.

The chemical name of Vardnenafil is

4-[2-Ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-9-methyl-7-propyl-3,5,6,8-tetrazabicyclo[4.3.0]nona-3,7,9-trien-2-one .

The chemical formula of Vardnenafil is C₂₃H₃₂N₆O₄S and it has a molecular weight of 488.604 g/mol.

The drug has the same chemical formula as sildenafil citrate, minus the fact that its nitrogen has a different position and the methyl group in the piperazine ring is substituted by ethyl ring.

Route of administration.

The route of administration is oral as Vardnenafil is mainly available in pill form. But this also affects the bioavailability (amount of effective drug in the systemic circulation), which decreases drastically. Only 15 % of this drug is available after the drug is completely digested. The degree to which the drug binds to the blood plasma / protein is 95 %. This is one of the reasons why the drug is so effective.

The half life (time after which only half of the active drug remain in the system) is only 4 to 5 hours. As a result of this, the drug continues to leave the body, which affects its efficacy. Men who are prescribed vardenafil are able to remain active for only a period of 4 to 5 hours as post that period, the reaction of the body to the drug (pharmacokinetics) is low.

Though the bioavailability of the drug is less that sildenafil citrate (40 %), it has the same effect due to its ability to bind with 95 % of protein, increasing its effect on the body.

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